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Dr. Thomas Goodwin, Dr. Michael Schmidt, Sunday, 9-22-13 September 23, 2013

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Dr. Thomas Goodwin, Dr. Michael Schmidt, Sunday, 9-22-13

Personalized Medicine for Human Space Flight


 Your Amazon Purchases Can Help Support The Space Show/OGLF (www.onegiantleapfoundation.org/amazon.htm)

Guests:  Dr. Michael Schmidt, Dr. Thomas Goodwin.  Topics:  We discuss the recent published reviewed paper by our guess, “Personalized medicine in human space flight: using Omics based analysis to develop individualized countermeasures that enhance astronaut safety and performance.”  Please direct all comments and questions regarding Space Show programs/guest(s) to the Space Show blog, http://thespaceshow.wordpress.com.  Comments and questions should be relevant to the specific Space Show program. Written Transcripts of Space Show programs are a violation of our copyright and are not permitted without prior written consent, even if for your own use. We do not permit the commercial use of Space Show programs or any part thereof, nor do we permit editing, YouTube clips, or clips placed on other private channels & websites. Space Show programs can be quoted, but the quote must be cited or referenced using the proper citation format. Contact The Space Show for further information. In addition, please remember that your Amazon purchases can help support The Space Show/OGLF. See www.onegiantleapfoundation.org/amazon.htm.  We welcomed both Dr. Michael Schmidt and Dr. Thomas Goodwin to this 1 hour 28 minute program to discuss their findings represented in their recent published & reviewed paper, “Personalized medicine in human space flight: using Omics based analysis to develop individualized countermeasures that enhance astronaut safety and performance.” I’ve posted this paper on The Space Show blog and I urge you to read it as I believe it will the way of the future for human spaceflight astronaut safety and enhancement.

We started our discussion with Dr. Schmidt stating the problem(s) with astronauts in the extreme space environment, longer mission duration stress, plus other factors.  Dr. Schmidt followed by Dr. Goodwin then explained and discussed personalized medicine in human space flight and the use of Omics analysis.  Their work was also applied to the emerging space tourism industry as well as for suborbital missions.  Regarding the suborbital flights, the interest seems to be more with the pilots who will be making many trips to space rather than the participant who will likely be doing it only once.  Our guests put forth the reasoning for personalized space flight medicine, we talked about the capabilities to do this screening and the studies today, what will be near term and what we can expect over the longer term as technologies develop.  Listeners asked about conventional mitigation strategies such as shielding, exercise, etc.  Our guests pointed out that they were not talking about eliminating the usual mitigation strategies but tailoring needs to an individual’s DNA and genetic makeup since  individual astronauts may have genetic and DNA differences that will respond better to a customized mitigation.  We talked about varying degrees of DNA stability & unstable DNA.  Much was said about the effects of RX medications and drug profiles.

In our second segment, we talked more about the suborbital flights and the interest in the pilots due to their repeat flights.  We talked about targeted RX medications for an individual, how medications are metabolized & how that might actually differ in the astronauts leading to customization.  Doug asked about a type of primate ISS experiment regarding fractionalized gravity.  Listeners also wanted to know about adding mass and cost to a mission due to personalized space flight medicine which as you will hear, was not the case.  In the concluding comments, our guests pointed out that personalized space flight medicine was going to be the future of human space flight.  Personalized and target DNA and genetic medicine is already starting to happen here on Earth so its extension to space is only natural.

Please post your comments/questions on The Space Show blog.  You can contact our guests through me.

Here is the published & reviewed paper by our guestsL  Schmidt and Goodwin Per Med Omics OSaD Review

Dr. Erik Seedhouse, Sunday, 3-11-12 March 11, 2012

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Dr. Erik Seedhouse, Sunday, 3-11-12


Guest:  Dr. Erik Seedhouse.  Topics:  We discussed his book, “Interplanetary Outpost: The Human and Technological Challenges of Exploring the Outer Planets,” the human factors issues & the technical issues for such missions.  You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, http://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We welcomed back Dr. Seedhouse to discuss his new book on interplanetary missions.  Remember, if you buy the book using the following Amazon URL, Amazon will make a contribution to The Space Show/OGLF (www.amazon.com/Interplanetary-Outpost-Technological-Challenges-Exploration/dp/1441997474/ref=onegiantlea20).  Dr. Seedhouse began our discussion by talking about the interplanetary mission research that has been done over the years and is still continuing though in a greatly reduced mode.  In this discussion, he referenced the HOPE Study for mission architecture to travel to Callisto, one of the moon’s of Jupiter.  He also talked about research going on with ESA regarding human hibernation and on this subject, we spend a considerable amount of time. Artificial gravity and radiation were discussed along with vision problems for astronauts having spent at least four months on orbit.

As we started the second segment,Marshall called in and wanted to know about athletic and sports games to pass the time for the crew on long spaceflights.  Dr. Seedhouse thought more of the idea to have some sort of sport or athletic game at the destination rather than on the spaceflight.  We also talked about what it would take to change attitudes and policy to undertake an interplanetary mission.  At one point in the discussion, our guest suggested we might be too soft in modern times to explore and that we were no longer as interested in exploring as we once were.  Make sure you hear this entire conversation.  We fielded more listener questions and calls, talked about humans being able to adapt to the space environment over a long period of time and genetic screening for crew selection.  We covered crew selection in some detail which then took us to the subject of bioethics which do not yet exist in any formal way for an interplanetary mission. Erik did include his version of an Interplanetary Bioethics Manual as Appendix II. We talked about pregnancy, pre-emptive surgery, death of a crew member, death of a family member back on Earth, waivers that would need to be signed by both crew and family members, and much more.  Toward the end of the program, our guest was asked about interplanetary propulsion systems and multigenerational crews.  Erik talked about the VASIMR and we asked lots of questions about the 2nd and 3rd generation members of the multigenerational crew and how to be sure they become doctors, engineers, and other positions needed for the crew’s survival and success.  We also talked about modernizing space suits and Erik told us about Blue Suit Days as a requirement for Canadian astronauts for space outreach support.

Please post your comments/questions on The Space Show blog URL above.


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