Dr. John Brandenburg, Sunday, 5-19-13 May 20, 2013Posted by The Space Show in Uncategorized.
Tags: Albert Einstein, Clementine Mission, cold fusion, cosmology, Dr. John Brandenburg, fringe physics, GEM Theory, gravity, Higgs boson, Kaluza-Klein, LENR, lunar meteor impact, Mach's Principle, mainstream physics, Max Planck, particle physics, physics frontier, plasma physics, quantum mechanics, Richard Feynman, science fiction, Shoemaker-Levy impact, Unified Field Theory
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Dr. John Brandenburg, Sunday, 5-19-13
Guest: Dr. John Brandenburg. Topics: Physics, cosmology, Unified Field Theory, Higgs-Boson. Please direct all comments and questions regarding Space Show programs/guest(s) to the Space Show blog, http://thespaceshow.wordpress.com. Comments and questions should be relevant to the specific Space Show program. Written Transcripts of Space Show programs are a violation of our copyright and are not permitted without prior written consent, even if for your own use. We do not permit the commercial use of Space Show programs or any part thereof, nor do we permit editing, YouTube clips, or clips placed on other private channels & websites. Space Show programs can be quoted, but the quote must be cited or referenced using the proper citation format. Contact The Space Show for further information.
We welcomed back Dr. John Brandenburg for an interesting science fiction and physics discussion for 2 hours and 7 minutes. We started our first segment with Dr. Brandenburg talking about the recent meteor impact on the Moon, parallels with the Shoemaker-Levy comet impact on Jupiter, and even referencing the Clementine Mission. We then moved into John’s science fiction writing which he usually does under the name of Victor Norgarde. However, his latest book project, a book that goes into the metaphysical realms and is titled “The Cosmic Jesus,” he uses his real name. Based on his discussion of the book with us, I hope to feature it with John on future Space Show program. Dr. Brandenburg then introduced us to the theories of Richard Feynman and John Wheeler and the impact of their work today.
In our second segment, Dr. Brandenburg talked about his GEM Tetra Unification Theory and the Higgs-Boson particle. In this discussion, our guest did use a moderately heavy physics language citing several theories and the works of others such as Kaluza-Klein theory so stay with us as we talked about hidden dimensions, quantum mechanics, force fields, LENR & cold fusion, Mach’s Principle and much more. John speculated on the Higgs being able to help us figure out how to reduce the mass of a spaceship so it could accelerate to the speed of light. As you will hear, our caller John Hunt who is now in Ft. Worth rather than Atlanta talked with our guest about not impacting the inside of the spaceship and the occupants in reducing the mass of the spaceship. At times, this was a very technical discussion. Later in the segment, Sandra in Seattle emailed in asking our guest to assign himself to either traditional physics, the frontier of physics, or the lunatic fringe of physics. This turned into a most interesting discussion about physics and each of the three classifications. You guess where Dr. Brandenburg placed himself in terms of the three classification descriptors. For most of the rest of the discussion, Dr. Brandenburg talked about physics, what it takes to get theories and ideas into the academic discussion and at some point accepted or at least seriously considered. Another listener emailed him for conference suggestions since John said that it was important to go to conferences, publish, present, etc. In Dr. Brandenburg’s closing remarks, he left us with a challenging question to consider!
Please post your comments/questions on The Space Show blog above. You can email Dr. Brandenburg through me at firstname.lastname@example.org.
Dr. William Bainbridge, Friday, 2-8-13 February 6, 2013Posted by The Space Show in Uncategorized.
Tags: CCI Games, citizen science, Dr. William Bainbridge, EVE Online, frontier development, Galaxy Zoo, gaming, JPL, NASA, NASA story telling, nuclear propulsion, pioneering, science fiction, Sean Smith (Vile Rat), space economic issues, Space Futures Space Survey, space industry knowledge and perceptions, space policy, The Committee for the Future, the next fifty years in space, The Syncon Process, U.S. space leadership, Vile Rat., virtual reality
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Dr. William Bainbridge, Friday, 2-8-13
Guest: Dr. William Bainbridge. Topics: The Space Futures Space Questionnaire about space exploration and the next fifty years. Please direct all comments and questions regarding Space Show programs/guest(s) to the Space Show blog, http://thespaceshow.wordpress.com. Comments and questions should be relevant to the specific Space Show program. Written Transcripts of Space Show programs are a violation of our copyright and are not permitted without prior written consent, even if for your own use. We do not permit the commercial use of Space Show programs or any part thereof, nor do we permit editing, YouTube clips, or clips placed on other private channels & websites. Space Show programs can be quoted, but the quote must be cited or referenced using the proper citation format. Contact The Space Show for further information.
We welcomed Dr. William Bainbridge to the program to discuss the Space Futures project which is to help define the future of space our space program for the next fifty years. Perceptions of informed, interested, and space conscious individuals are sought for the Space Futures space questionnaire. The questionnaire is based on years of prior research conducted by Dr. Bainbridge as well as other more recent surveys. You can read about the Space Future Questionnaires (different platforms are available for it) at http://convergentsystems.pbworks.com/w/page/16444389/FrontPage. If you use the Droid platform, click on the links that allow you download a free Droid APP which enables you to instantly transmit your survey responses to the survey data base. For everyone else, you can download the survey as a Word document which you can complete online and email to Dr. Bainbridge. The Word document questionnaire with 300 questions is at http://convergentsystems.pbworks.com/w/file/62227159/Space%20email%20survey.doc. Make sure you click on the DOWNLOAD tab in the upper left corner. There is a shorter 200 question Word document questionnaire on The Space Show blog. During our discussion, Dr. Bainbridge provided us with the history of this project, how the information has been and is now collected, processed, and used. We also talked about the importance of space aware people taking the time to complete the questionnaire. Lots of listeners asked Dr. Bainbridge questions about who should participate from Middle School students to those in the general population to people outside the U.S. All groups are welcome but as you will hear, it is very important to get the perceptions and opinions of those that have knowledge and expertise about space exploration and development. We talked about question groupings such as around topics including the Moon or Mars. We discussed changing trends overtime and current influences on our opinions such as today’s economic problems. I brought up the decades old Syncon Process and how some attitudes and perceptions are even stronger today than they were decades ago with Syncon. For example, attitudes including space benefitting all of humanity and more. This topic took us toward the virtual world, gaming to help increase space awareness and expertise. I mentioned the recent discussion re the lunar space elevator program this past Monday regarding CCI Games in Iceland. This was our cliff hanger as we went to our break waiting for Dr. Bainbridge’s comments about his being involved with CCI Games.
In our second segment of this 1 hr. 45 minute program, Dr. Bainbridge talked about his research with the CCI gaming product, EVE Online as he plays the game. He had much to say about the space awareness of this game and the team in Iceland that created it. He also said that Sean Smith, one of those slain in the terrorist attack in Benghazi, Libya was a player of EVE Online. His game name was “Vile Rat” and there is a huge outpouring of support and comments about him on the internet. Google Vile Rat to see these comments & news stories. We talked about other scientific games and new technologies for developing a space consciousness and expertise about space exploration. We talked about space and innovation along with frontier development, pioneering & what it means to both continue it or stop it for the future of a nation. John called to talk with Dr. Bainbridge about his surprise in taking the survey in finding out he was potentially more pessimistic about the future than he had thought he was because like so many others, he had expectations for more advancement in space exploration, development, even settlement than what exists with our present day reality. Dr. Bainbridge helped put these thoughts and realizations into context with our actual space exploration and development over the past decades. It’s a fascinating discussion and analysis, don’t miss it. Near the end of the program, a listener asked how to realize space as an investment rather than just another government expense item. We talked about better story telling by everyone concerned. Dr. Bainbridge also linked the survey questionnaires to this question because the results will help pinpoint our space insights along with the value stream. While there is a March 1 questionnaire due date, this is not a hard date and Dr. Bainbridge encouraged people to participate, even if later than March 1. Also, if someone wants hard copies of the questionnaire to distribute at a space conference or other event, perhaps even a Meetup, you can contact him for copies or you can download the questionnaire from the links provided above. Another idea is to make a simple flyer with the basic information and the URLs for space or related event distribution. I did the 300 questionnaire Word document and can’t wait to see the analysis. I certainly plan on bringing Dr. Bainbridge back to the program to discuss the project findings.
Please post your comments/questions on the blog. If you do the questionnaire, share your thoughts with us on the blog. If you want to contact Dr. Bainbridge, you can do so through me at email@example.com.
The shorter 200 question survey is available for download here:
Dr. Jeff Bell, Tuesday, 7-10-12 July 11, 2012Posted by The Space Show in Uncategorized.
Tags: " Cold War Space Programs, " SpaceX, "Halfway To Anywhere, aerospace engineering, air breathing motors for space vehicles, asteroid mining, B612 Foundation, Constellation, DCX, domestic economy, Dr. Jeff Bell, Dragon, Falcon 9. , fuel/weight ratios, human spaceflight destinations, human spaceflight rational, Mariner 4, Mars, nuclear propulsion, Pan Starrs Panoramic Survey Telescope, PhD programs & oversupply, Planetary Resources, Project Speed, ramjets, rocket engines, science fiction, scramjets, SLS, Space Shuttle, space shuttle conspiracy & the USSR, space telescopes, space vision, Sputnik Panic, V2, Venus, X30 National Aerospace Plane, X33
Dr. Jeff Bell, Tuesday, 7-10-12
Guest: Dr. Jeff Bell. Topics: Vintage Jeff Bell. We discussed a wide range of space history and current space projects from Dr. Bell’s perspective. You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, http://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We welcomed the return of Dr. Jeff Bell to The Space Show. This 2.5 hour marathon discussion with Dr. Bell was classic Jeff Bell with space history, his analysis of current projects, new space ideas, NASA, Congress and well, you name it. Dr. Bell had lots to say about many topics and for those of you familiar with Dr. Bell & his analysis, I promise you, you will not be disappointed with this discussion. Those of you new to Dr. Bell, hold onto your seat! Jeff started off with the cold war space history, X-33, and DCX. In doing so, he offered up his critique of the classic space book by G. Harry Stine, “Halfway To Anywhere: Achieving America’s Destiny In Space.” As to be expected, Dr. Bell provided a very hard hitting, factual, and critical analysis of these topics & the book. We also talked about the new company in Florida, Project Speed, and air breathing engines for space vehicles. Dr. Bell spent some time on this analysis including scramjets, ramjets and the National Aerospace Plane. When asked to confirm that little progress was being made from his perspective re space vehicles & even aviation, he cited the current military games going on in Hawaii, referencing the planes being used by the Air Force, Navy, & other military services, all to illustrate by example the points he was making. He put out the fire on nuclear propulsion based on economics & costs, & then in discussing human spaceflight (HSF), like so many others, he said the rational for it was difficult justify to Congress & the taxpayers. A listener asked Jeff he was biased in his analysis. Jeff said he was unbiased in his examination of the facts. This issue surfaced again later during our program. We then talked about a Washington Post article saying that our science field was over populated by excessive PhDs that cannot find work in their discipline (www.washingtonpost.com/national/health-science/us-pushes-for-more-scientists-but-the-jobs-arent-there/2012/07/07/gJQAZJpQUW_story.html?hpid=z1). This prompted listeners to reply and John made some excellent points about science PhDs that Jeff missed.
In our second segment, we started off with space visions, including the one from this program, followed by a discussion of the “Sputnik Panic” following theUSSR launch of Sputnik. We both had much to say about this event & its aftermath. Returning to the HSF rational, Jeff said there were two main problems with it. First, the very high cost. Second, the is no place to go that does not require massive technology & support to sustain life. He spent some time elaborating on this & responding to listener comments. Next up, Planetary Resources, asteroid mining, space telescopes, & Earth imaging. Dr. Bell took no prisoners in sharing his analysis with us. He did talk about several serious projects including the B612 project & Pan Starrs. As the program was ending, Dr. Bell had many positive things to say about the recently completed SpaceX Dragon & Falcon 9 flight, & the pork as he called it, SLS. Dr. Bell was very strong & clear in his support for SpaceX and their accomplishments.
Please post your comments/questions on The Space Show blog URL above.
The John Batchelor Show “Hotel Mars,” Wednesday, 6-20-12 June 21, 2012Posted by The Space Show in Uncategorized.
Tags: : John Batchelor, dark energy, dark matter, Dr. David Livingston, Dr. Seth Shostak, Exoplanets, extraterrestrial life, intelligent life elsewhere., Kepler Space Telescope, science fiction, SETI Organization, SETIcon II, The John Batchelor Show "Hotel Mars
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The John Batchelor Show “Hotel Mars,” Wednesday, 6-20-12
Guests: John Batchelor, Dr. Seth Shostak, Dr. David Livingston. Topics: SETIcon II Conference, science fiction & space science. You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, http://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Written transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. This program is archived on The Space Show website, podcasting, and blog sites with permission from John Batchelor. Please visit the John Batchelor Show website for more information about this fine program, www.johnbatchelorshow.com. During our 11.5 minute discussion, Dr. Shostak talked to us about the upcoming SETIcon II Conference sponsored by the SETI Organization. For details about the conference, visit www.seticon.org. The three of us talked about the programming, many of the guests and panels, but John also asked about the Kepler Space Telescope and finding exoplanets, the habitat zone, and life elsewhere off Earth. Dark matter, dark energy came up, along with the question which is addressed by this conference concerning if Earth is a miracle or if Earth is more common with life in other places even if not yet discovered by us here on Earth. In looking over the program agenda, you will recognize many of the speakers and panel members as Space Show guests and actual scientists and academics. You will hear me talk about why this is a special type of sci-fi conference. For those of you in the Bay Area or able to attend it this coming weekend, I strongly recommend you do so. It is affordable, it will be fun and above all, SETIConII will be information packed and educational.
If you have comments or questions about this program, please post them on The Space Show blog. If you want to email either John or Seth, send your note to me and I will forward it for you.
Sir Martin Rees, Sunday, 6-17-12 June 18, 2012Posted by The Space Show in Uncategorized.
Tags: " BBC Radio Lecture Series, " SpaceX, "From Here To Infinity: A Vision For The Future Of Science, conflict, consciousness, education, extraterrestrial life, fundamental physics, genetic modification, human spaceflight, interstellar travel, ISS, ISS science, Kepler Space Telescope, lunar commerce, microgravity, Neal Stephenson, political leadership, religion, risk averseness., robotic space missions, Roger Penrose, Royal Society, science, science fiction, science media, science teachers, Sir Martin Rees, space & astronomy for kids, space & long term planning, space & spiritualism, space settlement
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Sir Martin Rees, Sunday, 6-17-12
Guest: Sir Martin Rees. Topics: Science in our society, space development, political leadership, education & more. You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, http://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We welcomed back Sir Martin Rees to discuss his new book, “From Here To Infinity: A Vision For The Future Of Science.” Please remember that if you order this book from Amazon using www.amazon.com/Here-Infinity-Vision-Future-Science/dp/0393063070/ref=onegiantlea20, Amazon will make a contribution to The Space Show/One Giant Leap Foundation. Lord Rees started our discussion by talking about the amazing things we have learned about the cosmos in a very short period of time. He also explained that this new book is based on a series of lectures he did with BBC Radio. We also talked about science reporting in the media but we focused on teacher issues, both in the UK and the U.S. Another topic covered in his book was religion and science conflicts. An example cited was creationism. We also talked about space as a spiritual experience. We then talked about commercial space development with companies such as SpaceX, the high risk averseness of NASA, and the fact that private companies can take on more risks. Lord Rees expressed the view that for human spaceflight for sure, we will see more and more of it being done by the private sector. Our guest was asked about science on the ISS & he said it was hard to justify the ISS on the grounds of science. Jack called in to ask talk about the outstanding history programs on the Royal Society website, http://royalsociety.org/Podcasts-of-Library-events. He also mentioned famous sci-fi author Neal Stephenson, www.amazon.com/Quicksilver-The-Baroque-Cycle-Vol/dp/0380977427. Jack’s call was followed by John in Atlanta who talked about spirituality, consciousness, religion and the work of Roger Penrose. This led to an interesting discussion about the search for the unified theory and the difference in perspective with cosmology and fundamental physics. Our next topic was in response to a note from Fred about political leadership and space/science issues. Out last topic of the segment dealt with the Kepler Space Telescope (KST) and the search for extraterrestrial life. We asked questions about the impact on cultures were life off Earth discovered. Sir Martin had much to say about this subject.
In our second segment, we started out talking about science fiction. Sir Martin is fascinated by the ideas in science fiction so don’t miss his comments on this subject. Harold in Los Angeles asked if we might be slowing down in our rate of discovery of new science & space information. This is another terrific discussion. We then talked about the Earth’s population growth and the intellectual shift to Asia away from the west. Lord Rees talked about the need to balance out science and development in the under developed regions, focusing on Africa for example Later in the segment, we talked about bringing space resources back to Earth & our guest said the economics of doing this are still up in the air. Space settlement and returning to the Moon came up as did private missions to Mars and the asteroids. Our guest suggested that one way Mars missions might be possible in the future, but the probability of doing it near term & funding such a mission remains somewhat low at this time. Our guest also mentioned genetic modification for those that do settle off Earth but thought the ethics of doing it on Earth would make it unlikely to happen here.
If you have comments/questions for Sir Martin Rees, please post them on The Space Show blog.
Dr. John Jurist, Tuesday, 3-27-12 March 27, 2012Posted by The Space Show in Uncategorized.
Tags: astronaut medical information., bed rest studies, bisphosphonates, bone loss, bone mass, bone structure, centrifuge, Dr. John Jurist, extra-terrestrials, gene modification, human spaceflight, lunar gravity, Mars gravity., microgravity, microgravity exercise, muscular-skeletal system, NASA, orthopedic surgeons, penguin suit, piezoelectric, Pyrophosphates, radiation, science fiction, variable gravity research station in LEO
Dr. John Jurist, Tuesday, 3-27-12
Part 1, Bisphosphonate Usage in Microgravity
Guest: Dr. John Jurist. Topics: This is the first in a series of programs focused on the use of bisphosphonates to mitigate bone loss in long duration spaceflight. You are invited to comment, ask questions, & discuss the Space Show program/guest(s) on the Space Show blog, http://thespaceshow.wordpress.com. Comments, questions, & any discussion must be relevant & applicable to Space Show programming. Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We welcomed back Dr. John Jurist for the first of several programs devoted to understanding bone loss in microgravity & the use of prescription the bisphosphonate family of drugs to mitigate the problem. Dr. Jurist provided talking points which you can find below this summary on The Space Show blog. A significant portion of the second segment is devoted to understanding these talking points so follow along. We started our discussion with an explanation of the bone loss problem facing those in microgravity. Following this brief overview, Dr. Jurist told us about bisphosphonates, the origins of this drug, how it was developed, how its usage, what some of the side effects are, some of the trials that have been associated with the drug, & space/NASA studies. Later in this nearly hour long segment, we talked about the human population & what happens to our bone mass at various stages in our life. We talked about gender, racial, & ethnic differences in human bone mass issues. As you will hear, there are gender & other differences among our diverse population. This led us to asking about using targeted genetics in selecting crews for longer spaceflight missions. Genetic modification was mentioned, especially for the long term, but for the near term, looking for better exercise routines & pharmaceutical modification/treatment seem to hold the most promise. Dr. Jurist then talked about bisphosphonate side effects. Fast transit time to Mars or a long duration mission destination came up. As you will hear, even if you get to Mars faster, you still have the problem on the surface of Mars. The big problem is we have no credible information on what the gravity prescription for humans needs to be so we do not know if Martian gravity is sufficient to mitigate the problem. Next, we focused on the need for an orbiting centrifuge, we talked about the size & spin rate of the centrifuge, & what to actually test for in experiments. Dr. Jurist suggested that starting with 1/6th lunar gravity made sense because if it was sufficient, we would know that anything stronger than 1/6th would work. If not, we should probably next experiment with Martian gravity which is about 1/3rd Earth gravity.
In our second segment, Dr. Jurist referred to his talking points which you will find on The Space Show blog. We went line by line so follow along with us. Despite interruptions, John stayed on topic with the talking points. Listener questions asked about how gravity & having a load on bones works & what happens in space when that load is no longer present. We talked about the time prescription as well as the load factor (G force). Toward the end, John told us about a reviewed radiation article from 2010 showing that radiation impacted bone loss so the issue in space is more complex than just microgravity. Near the end, John got a question asking about ETs & their thin, pencil like shape making them perfectly designed for microgravity. This was both an interesting & fun discussion, bordering on science fiction. Another question asked about fish, reptilian, sea mammal, & bird bones. Our final topic dealt with the release of personal astronaut medical information & others & the ways for private information to be legally released to the public.
Please post your comments/questions on The Space Show blog URL above. Email for Dr. Jurist can be sent to me for forwarding.
Dr. John Jurist Bisphosphonate Talking Points:
Bisphosphonate show Tues 8:00-9:30 MDT Talking Points
Introduction: Bone is incredibly complex with many inter-related factorsGoal: Brief outline of cellular, structural, and functional aspects of bone metabolism in order to help listeners better understand and appreciate the potential role of bisphosphonates (which is the subject of a future show)
Bone Function: Two types of bone – compact and trabecular: Compact is outer shell, very dense, and fairly strong
Trabecular – also called spongy, contains spicules, plates, and struts of bone tissue with lots of vascular and fatty marrow, called trabecular
Remodeling: Bone is constantly being turned over or remodeled with portions being torn down and constituents dumped into bloodstream and other portions being built up from nutrients supplied by blood
Very rapid bone loss can lead to kidney stone formation from calcium dumped into blood
Turnover rate and the volume of total skeleton undergoing remodeling at any given time tends to go down with increasing age (remember this – important)
Balance between formation and resorption (tearing down) also tends to be lost after about age 30, lack of activity, certain hormonal imbalances, diseases, etc. with resorption predominating – one rationale for estrogen replacement therapy after menopause
Coordination between formation and resorption partly controlled by mechanical strains on bone tissue (called Wolff’s Law and issue in microgravity) – some evidence that mechanism is electrical in nature – rationale for electric and electromagnetic bone growth stimulators used to treat problematic fractures and improve incorporation of bone grafts
Cells: Stem cells differentiate (or specialize) into osteoprogenitor cells which differentiate into osteoblasts which are the bone formers
Osteoblasts create and secrete a protein and polysaccharide matrix called osteoid which is then calcified later to form the stuff we call bone
Interference in that calcification leads to rickets in children and osteomalacia (Greek for soft bones) in adults
Osteomalacia is often a result of interference in Vitamin D metabolism or dietary deficiencies
During bone formation, some osteoblasts “paint” themselves into a corner and get surrounded by bone – they are then called osteocytes and somehow maintain bone tissue
If osteocytes die in a volume of bone, that devitalized bone no longer undergoes remodeling but can eventually be replaced by a process called creeping substitution (remember comment about remodeling volume going down with age)
Devitalized bone can accumulate fatigue defects and eventually suffer fatigue fractures (called stress fractures – common in military recruits and deconditioned people who recondition too rapidly) if the defects are not replaced by new bone during creeping substitution
Other cells, with multiple nuclei and called osteoclasts, differentiate from marrow cells (monocytes and macrophages) which in turn differentiate from stem cells
Osteoclasts are the bone resorbers and destroyers
Autoradiographic studies show that their nuclei also came from osteocytes as well – presumably as they are resorbed during bone destruction process
Osteoclasts are related to multinucleated “giant cells” which are associated with inflammation in ways I do not understand
Bisphosphonates: Used over past 20-30 years in clinical medicine – brands include Actonel, Boniva, Fosamax, Aredia, etc.
Multiple mechanisms with different dose-response properties results in clinicians juggling doses and brands to get effects they want without effects they do not want
Bind to hydroxyapatite – the mineralized portion of bone tissue (calcified osteoid)
Inhibit bone resorption by inhibiting osteoclastic activity
Inhibition of resorption signals osteoblasts to slow down formation rates after a delay (but increases their lifetimes (anti-apotosis)
Bisphosphonates also inhibit mineralization of osteoid – especially at higher doses
That eventually reduces turnover rate and can lead to fatigue fractures with prolonged treatment (remember to call 1-800-BAD-DRUG)
Orthopedic surgeon (Frost atHenryFordHospital) figured out that cyclic therapy exploits delay in osteoblast inhibition relative to osteoclast activity and results in better bone mass gains
Bisphosphonates used in oncology to preserve bone and reduce pathological fractures with osteolytic tumors such as breast and prostate cancers. Also to counter hormonal blocking therapy used for prostate and breast cancers, but side effects increase with duration of treatment
Interesting sidelight with oncology is some evidence that bisphosphonates reduce risk of tumor metastasis to bone and other sites (somehow involving same signaling pathway as giant cells?)
Oral bisphosphonates cause stomach upset – advise staying upright for an hour or two after taking pill – how does this affect microgravity exposure?
Intravenous bisphosphonates get around oral gastric upset, but placing line or port has risks too (most oncology patients have ports during active treatment)
Also cause osteonecrosis – especially jaw which I believe is septic or infective – and atrial fibrillation (talk to Bill Rowe on this one since he is interested in heart physiology in space)
Bone quality: Turnover rates and percent of skeleton not devitalized important factors in determining bone strength – measuring bone mass by DEXA or other means is not the be all and end all in evaluating bone strength and risk of fracture.
My Goal: General background on bone physiology and function to aid in appreciating upcoming show(s) on bisphosphonates in space medicine