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The John Batchelor Show “Hotel Mars,” Wednesday, 3-13-13 March 14, 2013

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The John Batchelor Show “Hotel Mars,” Wednesday, 3-13-13

http://archived.thespaceshow.com/shows/1972-BWB-2013-03-13.mp3

Guests:  John Batchelor, Taber MacCallum, Dr. David Livingston:  Topics: Inspiration Mars flight details.  You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, https://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Written Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We do not permit the commercial use of any Space Show program or part thereof, nor do we permit Space Show programs to be edited, placed on YouTube, or other private channels & websites. Space Show programs can be quoted in news articles, papers, academic & research work but must be cited or referenced in the proper citation format. Contact Dr. Livingston for questions about our copyright and trademark policies which we do enforce.  This program is archived on The Space Show website, podcasting, and blog sites with permission from John Batchelor. Please visit the John Batchelor Show website for more information about this fine program, www.johnbatchelorshow.com.  Please note that there were some minor audio issues with this archive recording.

During our 11 minute plus discussion with Taber MacCallum of Paragon Space Development Corporation, we talked about the Inspiration Mars proposed human spaceflight flyby mission.  Some of the topics covered included the launcher, which space capsule would be used, the habitat for use when traveling to Mars, EDL back on Earth, crew size and gender, and life support

Please post any comments/questions you might have on The Space Show blog.  You can contact any of  us through drspace@thespaceshow.com.

 

John Batchelor Show Hotel Mars, Wednesday, 3-6-13 March 6, 2013

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John Batchelor Show Hotel Mars, Wednesday, 3-6-13

http://archived.thespaceshow.com/shows/1965-BWB-2013-03-06.mp3

Guests:  John Batchelor, Dr. Robert Zubrin, Dr. David Livingston:  Topics: Inspiration Mars, human spaceflight to Mars.  You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, https://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Written Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We do not permit the commercial use of any Space Show program or part thereof, nor do we permit Space Show programs to be edited, placed on YouTube, or other private channels & websites. Space Show programs can be quoted in news articles, papers, academic & research work but must be cited or referenced in the proper citation format. Contact Dr. Livingston for questions about our copyright and trademark policies which we do enforce.  This program is archived on The Space Show website, podcasting, and blog sites with permission from John Batchelor. Please visit the John Batchelor Show website for more information about this fine program, www.johnbatchelorshow.com.

During our 11 minute plus discussion with Dr. Zubrin, we talked about the Inspiration Mars proposed human spaceflight mission and the previous Athena Project Bob proposed in the mid-1990’s.  Bob talked about the orbital dynamics, cosmic radiation, microgravity, possible NASA mission support, and more.  Bob also spoke about the availability of hardware for the Inspiration Mars mission but the need for a new thermal protection system.

Please post any comments/questions you might have on The Space Show blog.  You can contact any of  us through drspace@thespaceshow.com.

Dr. Curt Bilby, Dr. Elizabeth Leffel, Monday, 10-22-12 October 23, 2012

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Dr. Curt Bilby, Dr. Elizabeth Leffel, Monday, 10-22-12

http://archived.thespaceshow.com/shows/1878-BWB-2012-10-22.mp3

Guests: Dr. Curt Bilby, Dr. Elizabeth Leffel.  Topics:  The RLIP76 protein by Terapio for radiation toxicity mitigation from multiple causes.  You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, https://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Written Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We do not permit the commercial use of any Space Show program or part thereof, nor do we permit Space Show programs to be edited, placed on YouTube, or other private channels & websites. Space Show programs can be quoted in news articles, papers, academic & research work, but must be cited or referenced using the proper citation format. Contact Dr. Livingston for questions about our copyright and trademark policies.  We welcomed Drs. Curt Bilby & Elizabeth Leffel to the program to discuss the use of the RLIP76 protein for radiation damage mitigation using this biologic medical product.  You can learn much more about RLIP76 at the Terapio website, www.terapio.com. Terapio won Honorable Mention at this year’s NewSpace Business Plan Competition where I met Dr. Leffel as she presented for the company at the competition. You can see Dr. Leffel’s presentation at www.spacevidcast.com/2012/07/27/newspace-2012-business-plan-competition-part-2.  Dr. Leffel starts her presentation at 26 minutes 25 seconds into the video. In starting today’s discussion, our guests explained RIP76 and how it works through the oxidative stress pathway.  We learned about the FDA Animal Rule being used given human radiation experiments are not allowed.  We also talked about FDA fast tracking RLIP76 approval in case of an emergency, plus how RLIP76 would probably be used for acute radiation syndrome as compared to a chronic radiation exposure as the treatment models differ.  Near the end of the first segment, NYC 1st responder Daniel called us with several questions applicable to his being an emergency 1st responder & likely to be closely involved in any nuclear terrorist event. We don’t often get a view of this world on The Space Show so I urge you to pay attention to Daniel’s questions & the discussion with our guests.

In our second segment, I asked Dr. Bilby questions about the venture capital model for pharmaceutical R&D, pricing, & national healthcare systems plus insurance companies blocking access to many of these cutting edge drugs due to their high cost.  Curt took us through the risks associated with the different stages of pharmaceutical R&D, clinical trials, & product distribution. We talked about the very high failure rate for new drug research & we were introduced to the term “valley of death” as applied to this process.  We talked more about the actual RLIP76 process, potential pricing of the product & public health policy that might control its use.  We had a caller ask about using RLIP76 on a one way Mars trip as a trial, wondering if the FDA would approve such an “experiment.”  Dr. Bilby explained why it was unlikely this would happen, then we talked about getting RLIP76 for a space use by going outside the U.S.  Listen to why that won’t work. We also talked about space radiation issues, the possible role of RLIP76 regarding these issues, plus NASA’s interest in working with Terapio in their research.  Doug called to cite Terapio as a perfect example of a space scalable business, a topic we talk often of on The Space Show. As the segment ended, I asked Dr. Bilby if Terapio was public or if it had plans to do an IPO anytime in the near future. He explained the mixture of government & private sector equity partners but no plans for an IPO at this time.

Please post your comments/questions on The Space Show blog.  You can email our guests through me.

Open Lines, Tuesday, 6-12-12 June 12, 2012

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Open Lines, Tuesday, 6-12-12

http://archived.thespaceshow.com/shows/1794-BWB-2012-06-12.mp3

Guests:  Open Lines with Dr. David Livingston.   Topics: A short film – Angelfish, human factors for space travel, artificial gravity, space communications, science fiction movies & long term science projects, risk taking.  You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, https://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. This is about a 2.5 hour Open Lines discussion.  We started by talking to Michael Tyburski, an independent film maker who made a short film, Angelfish, and used The Space Show clips in the background.  Michael described his film, why he put The Space Show in it, and more.  Visit www.michaeltyburski.com for more information.  Next, Dr. Jurist talked with us about artificial gravity & the chart he created to show just how big the radius would have to be to spin at 1G & other levels including lunar as well as Martian gravity.  This chart is on The Space Show blog so you can follow along with what Dr. Jurist talked about regarding artificial gravity and spin rates.  Our last caller for the first hour long segment was Jay who discussed the Space Literacy Foundation (www.spaceliteracy.org). Jay talked about the need for better space communications with the public as a way to facilitate more support for space.  He also responded to questions I asked him about myths dealing with our early space program and the general population.  If you are interested in what Jay is doing, contact him through his website.

In our second longer segment, Ron called in to talk about the history of the wheels on the Lunar Rover and an ad campaign by Goodyear that incorrectly describes the history of the rover wheels.  Ron talked about the use of piano wire, how the original wheels were made, who made them, and more.  The paper about this important history that we mentioned on air can be read at www.hq.nasa.gov/alsj/lrv_historical_origins.pdf.  We talked about the history of the lunar rovers, the cosmic radiation impact on them over time on the Moon, and their design which included harmonic drives and engineering to shield from lunar dust problems.  He mentioned a good source of information, a journal edited by Eric Jones & Ken Glover, the Apollo Lunar Surface Journal. You can find this journal at www.hq.nasa.gov/alsj.  Ron directed listeners to the document section for Apollo 15, 16, and 17.  John from Atlanta followed Ron, had much to say about the recent success of the Dragon & Falcon 9, then he talked about human factors, one way Mars missions as being suicidal, the regulatory environment & the possibility of excessive or restrictive regulations.  We also talked about the new sci-fi movie, Prometheus.  The article I mentioned about the movie can be read at http://cavalorn.livejournal.com/584135.html.  If you plan on seeing the movie, I suggest you see the movie first, then read the article which is titled Prometheus Unbound: What The Movie Was Actually About.  It is written by Cavalorn.  Tim was our final caller.  He took issues with human factors medicine & Dr. Rowe. Also the risk of over regulation, especially if someone dies going to space. He expressed his thoughts on other things as well. While our discussion was civil, as you will hear, I did not agree with much of what he advocated.  I urged him and other space enthusiasts to be more inclusive of other ideas for space exploration and development rather than just believing their way is the best or even the only way.

If you have comments/questions, post them on the blog.  If you want to email those that called us, send your note to me & I will forward it for you.

Artificial gravity

Drs. Adrian LeBlanc, Thomas Lang & John Jurist, Sunday, 5-6-12 May 6, 2012

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Drs. Adrian LeBlanc, Thomas Lang & John Jurist, Sunday, 5-6-12

NASA Bone Loss & Bisphosphonate Study

http://archived.thespaceshow.com/shows/1769-BWB-2012-05-06.mp3

Guests:  CLASSROOM:  Dr. Adrian LeBlanc, Dr. Tom Lang, Dr. John Jurist.  Topics:  Bone loss issues for human spaceflight & the use of bisphosphonates for mitigation.  You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, https://thespaceshow.wordpress.com and The Space Show Classroom blog, http://spaceshowclassroom.wordpress.com.  Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright.  In addition, at the end of this summary, you will find links to relevant papers for our discussion as provided us by Dr. Lang.  We welcomed Dr. Adrian LeBlanc, Dr. Tom Lang and Dr. John Jurist as co-host to discuss the NASA bisphosphonate and bone loss study in progress.  Dr. LeBlanc along with his associate in Japan, Dr. Toshio Matsumoto, are leading this study and Dr. Lang is part of the team.  We started our discussion with Dr. LeBlanc providing us with a brief historical overview of bone loss issues of concern to NASA since the early days of the space program.  We talked about Skylab, Mir, the use of the DEXA scan, the use of quantitative computer tomography (QTC) and CT scans through to the ISS, Space Shuttle, and current research projects.  Our discussion was technical at times so if you need to look up or Google a technical term, please do so. In addition, we had some audio issues with the phone line used by Dr. LeBlanc as he faded in and out from time to time.  We apologize for any inconvenience this might have caused.  The first segment went through the bone loss issues, problems, consequences, & the methodologies involved in analyzing the conditions encountered by the astronauts participating in these studies.  Issues we discussed included the use of prescription drugs in space, long term use of bisphosphonates, risk factors for spontaneous hip fractures, exercise programs, bone strength, bone mass, the impact of radiation, skeletal recovery back on Earth after spaceflight to something different than before the spaceflight took place as well as the implications for astronauts as they age.  We talked about using artificial gravity to mitigate bone loss.  You might be surprised to learn that using partial gravity may not help matters.  Bisphosphonates do seem to help and will possibly play a role with exercise as we move to long duration spaceflight but we are in the very early stages of fact finding on these issues.  We also discussed informed consent with the astronauts regarding their participation in these and other experiments.

In the second segment, a listener asked about the relevance of this type of space research to the taxpayer who funds it and to the general population.  Our three guests responded to this question, explaining why the research is relevant and important. Don’t miss their answers.  We then talked about following the astronauts here on Earth to see the continued impact of having been in space on their bones as they age.  We learned that bone changes after being in space for four weeks or more and it is important to follow these changes as part of the aging process.  Our guests talked about calcium excretion issues in space and the risk this causes for a renal stones.  Bisphosphonates may inhibit calcium excretion which would help mitigate this risk.  Near the end of our discussion, we learned about new medications being developed that are more advanced than the bisphosphonates we have today.  We also talked about the competition with astronauts for different scientific experiments.  As Dr. Jurist pointed out, we really do need lots more human spaceflight!  At the end a listener asked about bed rest studies and our guests provided us with the basics.  If you are interested, visit https://bedreststudy.jsc.nasa.gov.  Our guests made important closing comments and take away points.

Please post comments/questions on The Space Show and Classroom blogs.

Dr. Lang provided us with these links that will be of interest to us all.  These documents can be accessed without a subscription to the journals. These papers provide some background to the problem of bone loss in spaceflight, the recovery of bone after spaceflight and use of CT and the use of CT-based finite element modeling to assess bone loss.

Cortical and Trabecular Bone Mineral Loss From the Spine and Hip in Long-Duration Spaceflight http://onlinelibrary.wiley.com/doi/10.1359/JBMR.040307/full

Adaptation of the Proximal Femur to Skeletal Reloading After Long-Duration Spaceflight http://onlinelibrary.wiley.com/doi/10.1359/jbmr.060509/full

Reduction in proximal femoral strength due to long-duration spaceflight http://scholar.google.com/citations?view_op=view_citation&hl=en&user=0zFSO9sAAAAJ&cstart=20&citation_for_view=0zFSO9sAAAAJ:4DMP91E08xMC

Click on link on right “[PDF] from http://cof.org.cn ” for free pdf copy of the report.