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Dr. William (Bill) Rowe, Sunday, 8-31-14 September 1, 2014

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Dr. William (Bill) Rowe, Sunday, 8-31-14

http://archived.thespaceshow.com/shows/2307-BWB-2014-08-31.mp3

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Guest:  Dr. William (Bill) Rowe.  Topics:  Cardiovascular & other issues for long duration human spaceflight.  Please direct all comments and questions regarding Space Show programs/guest(s) to the Space Show blog, https://thespaceshow.wordpress.com.  Comments and questions should be relevant to the specific Space Show program. Written Transcripts of Space Show programs are a violation of our copyright and are not permitted without prior written consent, even if for your own use. We do not permit the commercial use of Space Show programs or any part thereof, nor do we permit editing, YouTube clips, or clips placed on other private channels & websites. Space Show programs can be quoted, but the quote must be cited or referenced using the proper citation format. Contact The Space Show for further information. In addition, please remember that your Amazon purchases can help support The Space Show/OGLF. See http://www.onegiantleapfoundation.org/amazon.htm.   For those listening to archives using live365.com and rating the programs, please email me as to why you assign a specific rating to the show. This will help me bring better programming to the audience.

We welcomed Dr. Bill Rowe back to the program to discuss cardiovascular issues for human spaceflight & EVAs, plus many other issues pertaining to long duration spaceflight.  Note that we experienced serious phone line issues with Bill about 12 minutes into the program forcing us to stop for repairs.  Evidently the fiber phone lines now serving Dr. Rowe cause broadcast equipment problems.  Bill was able to go to a neighbor’s house to do the show but you will hear some line issues plus unusual cuts as I spliced together part of his opening to the point we were able to resume with a good phone line.  Once past that point, there were no further phone line issues.  During the first segment of our 2 hour 11 minute program, Dr. Rowe introduced us to his discussion main points and we began using his website for references throughout the show.  It is important to be on his website and go where he points at various times in the discussion (see http://www.femsinspace.com).  While parts of the discussion relied on medical terms and descriptions, our guest did an excellent job of breaking it down for us non-medical types to easily understand the information he was sharing with us.  Among the issues we talked about were cardiac issues that don’t present symptoms, plus the problems with increased adrenalin secretion in the body which happens in space.  Dr. Rowe spent significant time discussing the adrenalin issues citing known astronaut examples.  In fact when talking about the adrenalin levels in space, he said that within five days of being in space the levels are twice that of being on Earth.  Another issue brought up was possible cardiovascular damage for excessive exercise and here he cited the research projects he had been involved in with marathon running athletes.  He strongly suggested the use of regularly taken electrocardiograms on the crews while in space.  Next, Dr. Rowe talked about EVA issues, specifically cooling.  He explained other risks and made the case for future robotic EVA missions instead of human mission.  Before the segment ended, he had much to say about exercise in space.

In our second segment, Bill reviewed for us his comments on oxidative stress and suggested we follow along with his website submarine model, http://www.femsinspace.com/Oxidative_stress.htm.  A listener then emailed in that the ISS did have an ultrasound on board which could be used for the purposes Dr. Rowe suggested (see http://www.nasa.gov/mission_pages/station/research/benefits/ultrasound.html).  Bill talked more about lunar dust toxicity plus magnesium and calcium usage in space and in general.  He referenced former astronaut Jim Irwin losing consciousness for a brief time on the Moon & he provided the reference for that fact.  Rodent research on the ISS was discussed, then he got a listener question about possible different health standards for government trained and fit astronauts as compared to space tourists and possible private sector astronauts.  Near the end of our discussion, space tourism came up and he pointed out risks for the middle age, overweight segment of the space tourism market.  Bill spoke to pharmaceutical use in space and the issues with it.  Just before ending our discussion, he pointed out that for Mars he thought an all female crew was best given the advantages they have over men.  He did explain his comment.

If you have comments/questions, post them on TSS blog above.  You can reach Dr. Rowe through his website or me.

Dr. Curt Bilby, Monday, 2-17-14 February 18, 2014

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Dr. Curt Bilby, Monday, 2-17-14

http://archived.thespaceshow.com/shows/2189-BWB-2014-02-17.mp3

Guest:  Dr. Curt Bilby.  Topics:  Update on developing RLIP 76 as a radiation countermeasure drug as we as for possible use in space.  Please direct all comments and questions regarding Space Show programs/guest(s) to the Space Show blog, https://thespaceshow.wordpress.com.  Comments and questions should be relevant to the specific Space Show program. Written Transcripts of Space Show programs are a violation of our copyright and are not permitted without prior written consent, even if for your own use. We do not permit the commercial use of Space Show programs or any part thereof, nor do we permit editing, YouTube clips, or clips placed on other private channels & websites. Space Show programs can be quoted, but the quote must be cited or referenced using the proper citation format. Contact The Space Show for further information. In addition, please remember that your Amazon purchases can help support The Space Show/OGLF. See www.onegiantleapfoundation.org/amazon.htm.

We welcomed back Dr. Curt Bilby, CEO of Terapio ( http://terapio.com), to update us on progress with the radiation countermeasure drug RLIP 76, including its potential use to combat and reduce space radiation risks.  We had a one hour update with Dr. Bilby which started with the basics of RLIP 76 which is a naturally occurring protein in the human body.  Dr. Bilby went through the basics with us, told us that since he was last on the show, they have stabilized the shelf life of the product by being able to store it as a white powder and then when needed mix it with saline.  He described the pathway in the body by which RLIP 76 works which is really a supplement to what the body already produces.  We talked about their experimentation and testing under what is known as the FDA Animal Rule which he explained in detail to us.  He also talked about toxicology studies as well as the type of radiation used in testing the product by the independent testing labs at the University of Indiana and Maryland under the management of the NIH.  We discussed the potential uses for RLIP 76 which are prioritized for first responders and those injured but it does have a potential application for space.  Listeners asked our guest several questions about its potential use in space, on the way to Mars, on the surface of Mars, and even on the lunar surface for a lunar settlement.  At one point later in our discussion, I suggested that being able to use RLIP 76 on a lunar settlement a decade or so out might be the first use of it if we escape a nuclear accident, nuclear terrorist attack, etc.  He said such a first usage would be a dream come through as it would mean there were no nuke accidents or attacks and we had a settlement on the Moon!  We did talk at length about the two types of animals used in the testing, plus moving to human trials and what information is sought from the human trials.  We also talked about production and manufacturing for RLIP 76 and I asked if they had future plans for outsourcing the production to another country.  Near the end of our discussion, Dr. Bilby went through the four phases of testing with us as required by the FDA. We also talked extensively about the FDA Emergency Use Authorization for any drug and a listener wanted to know if a Mars mission could apply & be approved for using RLIP 76 as part of their life support mission planning.  Just as the show ended, Doug sent in an email asking about the probability of NASA increasing the amount of radiation allowed if the crews used RLIP 76.  Dr. Bilby answered him by saying pharmaceuticals might change the profile & exposure levels as current standards are for unmedicated crews.  But it was far from certain & NASA might not be the determining agency on the matter.

Post your comments/questions on TSS Blog.  You can contact Dr. Bilby through me or his website.

Dr. Thomas Goodwin, Dr. Michael Schmidt, Sunday, 9-22-13 September 23, 2013

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Dr. Thomas Goodwin, Dr. Michael Schmidt, Sunday, 9-22-13

Personalized Medicine for Human Space Flight

http://archived.thespaceshow.com/shows/2090-BWB-2013-09-22.mp3

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Guests:  Dr. Michael Schmidt, Dr. Thomas Goodwin.  Topics:  We discuss the recent published reviewed paper by our guess, “Personalized medicine in human space flight: using Omics based analysis to develop individualized countermeasures that enhance astronaut safety and performance.”  Please direct all comments and questions regarding Space Show programs/guest(s) to the Space Show blog, https://thespaceshow.wordpress.com.  Comments and questions should be relevant to the specific Space Show program. Written Transcripts of Space Show programs are a violation of our copyright and are not permitted without prior written consent, even if for your own use. We do not permit the commercial use of Space Show programs or any part thereof, nor do we permit editing, YouTube clips, or clips placed on other private channels & websites. Space Show programs can be quoted, but the quote must be cited or referenced using the proper citation format. Contact The Space Show for further information. In addition, please remember that your Amazon purchases can help support The Space Show/OGLF. See www.onegiantleapfoundation.org/amazon.htm.  We welcomed both Dr. Michael Schmidt and Dr. Thomas Goodwin to this 1 hour 28 minute program to discuss their findings represented in their recent published & reviewed paper, “Personalized medicine in human space flight: using Omics based analysis to develop individualized countermeasures that enhance astronaut safety and performance.” I’ve posted this paper on The Space Show blog and I urge you to read it as I believe it will the way of the future for human spaceflight astronaut safety and enhancement.

We started our discussion with Dr. Schmidt stating the problem(s) with astronauts in the extreme space environment, longer mission duration stress, plus other factors.  Dr. Schmidt followed by Dr. Goodwin then explained and discussed personalized medicine in human space flight and the use of Omics analysis.  Their work was also applied to the emerging space tourism industry as well as for suborbital missions.  Regarding the suborbital flights, the interest seems to be more with the pilots who will be making many trips to space rather than the participant who will likely be doing it only once.  Our guests put forth the reasoning for personalized space flight medicine, we talked about the capabilities to do this screening and the studies today, what will be near term and what we can expect over the longer term as technologies develop.  Listeners asked about conventional mitigation strategies such as shielding, exercise, etc.  Our guests pointed out that they were not talking about eliminating the usual mitigation strategies but tailoring needs to an individual’s DNA and genetic makeup since  individual astronauts may have genetic and DNA differences that will respond better to a customized mitigation.  We talked about varying degrees of DNA stability & unstable DNA.  Much was said about the effects of RX medications and drug profiles.

In our second segment, we talked more about the suborbital flights and the interest in the pilots due to their repeat flights.  We talked about targeted RX medications for an individual, how medications are metabolized & how that might actually differ in the astronauts leading to customization.  Doug asked about a type of primate ISS experiment regarding fractionalized gravity.  Listeners also wanted to know about adding mass and cost to a mission due to personalized space flight medicine which as you will hear, was not the case.  In the concluding comments, our guests pointed out that personalized space flight medicine was going to be the future of human space flight.  Personalized and target DNA and genetic medicine is already starting to happen here on Earth so its extension to space is only natural.

Please post your comments/questions on The Space Show blog.  You can contact our guests through me.

Here is the published & reviewed paper by our guestsL  Schmidt and Goodwin Per Med Omics OSaD Review

Dr. William (Bill) Rowe, Sunday, 6-10-12 June 11, 2012

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Dr. William (Bill) Rowe, Sunday, 6-10-12

http://archived.thespaceshow.com/shows/1792-BWB-2012-06-10.mp3

Guest:  Dr. William (Bill) Rowe.  Topics:  Space medicine, magnesium, calcium & astronaut heart problems, oxidative stress & exercise protocols in space.  You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, https://thespaceshow.wordpress.com. Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We welcomed back Dr. Bill Rowe to further discuss certain aspects of human spaceflight (HSF) and space medicine.  Please note that all Space Show programs are educational programs.  This particular interview with Dr. Rowe is no exception.  As an educational program, Dr. Rowe, at the end of the interview, offered to respond to your serious comments & questions posted on the blog and said you could email him through his website, www.femsinspace.com.  Unlike most space medicine discussions, Dr. Rowe goes into lots of details on several key issues.  I have no doubt that some of you will reject, challenge, and not like what you hear. Some of you will take issue with Dr. Rowe & be critical of this program. You might even see him as being negative though that is not the case, but he is definitely scientific. I urge you to discuss disagreements, challenges, & issues with him.  Civility is the only requirement.  During our first hour of this nearly 2.5 hour discussion, Dr. Rowe started out by going over astronaut cardiac issues, referring to former astronauts Jim Irwin & Dave Scott on Apollo 15 pertaining to issues with Irwin’s hear rate.  The articles he mentions on his website are in the upper left hand corner of the home page.  Dr. Rowe then segmented into the first of many magnesium discussions & oxidative stress, using his submarine analog, (www.femsinspace.com/Oxidative_stress.htm.  Microgravity exercise routines were discussed along with the need to get rid of excessive body heat.  Dr. Rowe had much to say about the inadequacy of current on orbit exercise routines & heat.  He also talked about plasma leakage, the loss of magnesium, & what this does in space.  Also in this segment, he went over the Chinese Taikonaut requirements for female crew members, making the case for an all female crew. Don’t miss what he had to say about this.  Our last topic in this segment was 1G and artificial gravity.

In our second longer segment, Dr. Rowe talked about recent studies pertaining to calcium usage & he brought this home to HSF.  We talked about the importance of the calcium-magnesium ratio. Caller John introduced us to the issue of Vit. D3 & calcium.  Tim called to make some good points about artificial gravity in terms of needed data points.  He did not agree with the all female crew suggestion.  Next, Dr. Rowe talked about the gastrointestinal lining, iron, & bone issues in space.  Dr. Rowe also referred to anthropological studies to see how some groups habits might positively impact skeletal muscle issues in space. Issues with high adrenalin levels were discussed throughout the program along with possible treatment/intervention tools.  At the end, we learned that resolving these complex issues is not just a matter of more money.  I also asked Dr. Rowe about private Mars missions & one way trips with private crews ignoring space medicine factors.  He called them dreamers but in the end if they want to go knowing the risks, they should be able to go.  Dr. Rowe said his research & comments were focused on scientific HSF missions, not the dreamer type missions we often hear & read about in the media.

Post your comments/questions on The Space Show blog.  You can email Dr. Rowe through his website.

Dr. William (Bill) Rowe, Sunday, 1-22-12 January 23, 2012

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Dr. William (Bill) Rowe, Sunday, 1-22-12

http://archived.thespaceshow.com/shows/1695-BWB-2012-01-22.mp3

Guest: Dr. William (Bill) Rowe.  Topics:  Space medicine issues, magnesium issues, microgravity, ISS experiments, and more.  You are invited to comment, ask questions, and discuss the Space Show program/guest(s) on the Space Show blog, https://thespaceshow.wordpress.com.  Comments, questions, and any discussion must be relevant and applicable to Space Show programming. Transcripts of Space Show programs are not permitted without prior written consent from The Space Show (even if for personal use) & are a violation of the Space Show copyright. We welcomed back to the show Dr. Bill Rowe for updates on his presentations in China and elsewhere, his continued research on the role of magnesium in space medicine, the role of telomeres and gender crew issues for long duration spaceflight including trips to Mars.  During the first segment of our two hour plus program, Dr. Rowe directed us to many of the pages, articles, and documents on his website, www.femsinspace.com.  I urge you to access the pages he directs us to at various times during his talk and follow along with him.  This is important.  In this segment, we talked about the latest telomere research and its application to space flight.  Bill proposed ISS rat experiments and what the experiments should tell us.  He also talked about the role of magnesium deficiency in cells in spaceflight.  He talked about the need to develop a subcutaneous replenishable silicon device/pump to deliver magnesium and explained why this was essential.  Dr. Rowe talked about cardio-vascular issues in spaceflight in the context of magnesium and the overall issues of vascular disease.  This took us into the area of gender lifespan differences and studies showing that an all female crew to Mars might be desirable.  Also in this segment, Dr. Rowe talked extensively about oxidative stress and referred us to his submarine diagram on his website, www.femsinspace.com/Oxidative_stress.htm.  Marshall called in to talk about the ISS and the need for artificial gravity, partial gravity, or 1 G.  Dr. Rowe said 1 G was essential for humans.  Dr. Paul Dear called in from the UK with several questions, including asking about the initiating events for the body to sense microgravity down at the cellular level.  Bill & Dr. Dear also talked about genomic selection for astronauts. 

In the second segment, Dr. Rowe continued his discussion of the first segment topics and his proposed rat experiment regarding telomeres. Many listener calls and emails came in and Dr. Rowe expanded the discussion to the role of calcium for space flight and the calcium/magnesium ratio or relationship.  He was asked why magnesium was not discussed by most human factors space medicine doctors. Dr. Jurist was also asked this question during his call, listen to what they said in response to this question.  Bill talked about exercise routines for spaceflight & said it was a challenge to know the right exercise RX.  Don’t miss his comments on this issue. Near the end, he used Columbus and sailing ships as an example saying we are not ready for long duration spaceflight or a trip to Mars.  Listen to how he and I explained this during the closing comments for the show as I helped Bill phrase his analogy. 

Post your comments/questions for Dr. Rowe on The Space Show blog URL above. Dr. Rowe can be reached via his website.